CUSTOM ITEM: Guard Column cartridges, Bidentate C8 replacement, 2.0 mm ID x 10 mm long cartridges packed with 5 um, 300 A phase. Cogent TYPE-C Brand. 5/PK.
Additional Info:
The 40008‑PG2‑3 Cogent Bidentate C8 Guard Column Cartridges are replacement cartridges designed to protect analytical HPLC columns in large‑pore (300 Å) separations, especially when working with biomolecules or complex sample matrices.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 5 µm, 300 Å TYPE‑C™ silica hydride Bidentate C8 phase
Constructed with stainless steel bodies and SS frits
Each unit is individually packaged in a protective Delrin™ case to prevent drying, contamination, or damage.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm Analytical Columns
These guard cartridges are optimized for:
2.1 mm ID analytical HPLC columns
LC‑MS and low‑flow applications
Wide‑pore / biomolecule separations
Proper guard column matching ensures:
Minimal band broadening
Maintained resolution and efficiency
Consistent method performance
Why Use 300 Å Guard Cartridges
The 300 Å pore size is specifically designed for:
Peptides and proteins
Larger molecular weight compounds
Complex biological or matrix‑rich samples
Compared to 100 Å phases, 300 Å:
Improves accessibility for larger molecules
Reduces steric hindrance effects
Provides more reliable recovery of biomolecules
Why Use Replacement Guard Cartridges
Analytical columns are vulnerable to:
Particulate contamination
Strongly retained compounds
Biological or complex matrix fouling
Irreversible adsorption
The 40008‑PG2‑3 cartridges act as a sacrificial barrier, helping to:
Extend analytical column lifetime
Maintain chromatographic performance
Reduce downtime and replacement costs
Improve reproducibility in complex methods
Cartridges can be replaced quickly without disturbing the analytical column setup.
Bidentate C8 Guard Phase Matching
Using the same stationary phase as your analytical column ensures:
Matched retention and selectivity
No change in method behavior
Seamless analyte transfer to the analytical column
Compared to C18:
Reduces excessive hydrophobic retention
Improves recovery of amine‑containing analytes
Provides alternative selectivity for complex samples
Cogent TYPE‑C™ Advantages
Silica Hydride Surface
Reduced silanol interactions
Improved peak shape for basic and polar compounds
Lower secondary retention effects
Faster Equilibration
Reduced cycle times
Increased analytical throughput
Durability
Resistant to hydrolysis
Long cartridge lifetime
Stable under demanding analytical conditions
Typical Applications
LC‑MS biomolecule analysis
Peptides and protein separations
Pharmaceutical and bioanalytical workflows
Complex biological matrices
Analytical methods requiring wide‑pore stationary phases
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable